{"id":99,"date":"2018-05-02T14:25:07","date_gmt":"2018-05-02T14:25:07","guid":{"rendered":"http:\/\/cdmf.org.br\/en\/?p=99"},"modified":"2019-12-20T14:33:56","modified_gmt":"2019-12-20T14:33:56","slug":"novel-technique-achieves-32-fold-increase-in-bactericidal-capacity-of-nanoparticles","status":"publish","type":"post","link":"https:\/\/cdmf.org.br\/en\/2018\/05\/02\/novel-technique-achieves-32-fold-increase-in-bactericidal-capacity-of-nanoparticles\/","title":{"rendered":"Novel technique achieves 32-fold increase in bactericidal capacity of nanoparticles"},"content":{"rendered":"\n<p><strong>By Elton Alisson&nbsp; |&nbsp; Ag\u00eancia FAPESP<\/strong>&nbsp;\u2013 In recent decades, various research groups in the field of materials science have embarked on a race to develop new techniques capable of producing nanometric silver particles and enhancing the optical, catalytic and bactericidal properties of silver. A nanometer is one billionth of a meter.<\/p>\n\n\n\n<p>Researchers affiliated with the Center for Development of Functional Materials (<strong><a href=\"http:\/\/cepid.fapesp.br\/en\/centro\/12\" target=\"_blank\" rel=\"noreferrer noopener\">CDMF<\/a><\/strong>), one of the Research, Innovation and Dissemination Centers (<strong><a href=\"http:\/\/cepid.fapesp.br\/en\/home\" target=\"_blank\" rel=\"noreferrer noopener\">RIDCs<\/a><\/strong>) funded by FAPESP, have taken a step forward in this contest.<\/p>\n\n\n\n<p>The researchers developed a new technological approach that generated silver nanoparticles with 32 times the bactericidal capacity of those currently used in food packaging, orthotics, and hospital and medical materials, among others.<\/p>\n\n\n\n<p>The results of the study, conducted by researchers from the Federal University of S\u00e3o Carlos (UFSCar) and S\u00e3o Paulo State University (UNESP) in Brazil and from Spain\u2019s Jaume I University and the Technical University of Liberec in the Czech Republic, were&nbsp;<strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-018-19270-9\" target=\"_blank\" rel=\"noreferrer noopener\">published<\/a><\/strong>&nbsp;in&nbsp;<em>Scientific Reports<\/em>.<\/p>\n\n\n\n<p>\u201cWe succeeded in developing a novel solution for the production of silver nanoparticles that differ from those currently in existence and have far greater bactericidal capacity,\u201d said Elson Longo, CDMF\u2019s executive director and a professor at UFSCar, which hosts CDMF, in an interview given to&nbsp;<strong>Ag\u00eancia FAPESP<\/strong>.&nbsp;<\/p>\n\n\n\n<p>Three years ago, CDMF\u2019s researchers developed an innovative method of obtaining nanocomposites comprising silver nanoparticles coupled to a silver tungstate semiconductor crystal by transmission electron microscopy.<\/p>\n\n\n\n<p>Using this technique, which involves electron-beam irradiation of silver tungstate, they produced promising bactericides whereby the silver tungstate semiconductor attracts bacterial agents that are then are neutralized by silver nanoparticles.<\/p>\n\n\n\n<p>Large-scale production of these materials for real-world applications using this technique, however, is limited by the high cost of transmission electron microscopes.<\/p>\n\n\n\n<p>\u201cThe transmission electron microscope used to obtain this material costs approximately 1.3 million euros,\u201d Longo said. \u201cThis makes large-scale production of the material completely unaffordable.\u201d<\/p>\n\n\n\n<p>To scale up production of these nanocomposites using a more competitive method, the researchers developed a novel technique consisting of pulsed laser irradiation of a silver tungstate semiconductor, with each pulse lasting only a femtosecond \u2013 one millionth of one billionth of a second (10<sup>-15<\/sup>&nbsp;s).<\/p>\n\n\n\n<p>Analysis of the irradiated samples showed that interaction between the silver tungstate semiconductor and the femtosecond laser gave rise to large numbers of microstructures, which they characterized by transmission electron microscopy and found to be of two different types.&nbsp;<\/p>\n\n\n\n<p>\u201cThe new technique we developed resulted both in silver nanoparticles left on the semiconductor and in silver clusters,\u201d Longo said.<\/p>\n\n\n\n<p>To measure the bactericidal activity of the materials, the researchers placed samples of them in contact with methicillin-resistant strains of&nbsp;<em>Staphylococcus aureus<\/em>&nbsp;(MRSA), a bacterium that is resistant to numerous antibiotics and is frequently at the root of hospital-acquired infections.<\/p>\n\n\n\n<p>Microscopic analysis showed a 32-fold increase in bactericidal activity for the laser-irradiated samples compared with silver nanoparticles produced by electron-beam irradiation.&nbsp;<\/p>\n\n\n\n<p>\u201cThe new technique offers the possibility of obtaining high-performance bactericidal compounds that are easy to produce,\u201d Longo said.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Potential applications<\/strong><\/h4>\n\n\n\n<p>The researchers have applied for a patent on the new technique and the two new classes of silver nanoparticle obtained by the technique.<\/p>\n\n\n\n<p>The idea is to license the technology to Nanox, a spinoff from CDMF based in S\u00e3o Carlos, S\u00e3o Paulo State, and supported by FAPESP\u2019s Innovative Research in Small Business Program (<strong><a href=\"http:\/\/www.bv.fapesp.br\/en\/3\" target=\"_blank\" rel=\"noreferrer noopener\">PIPE<\/a><\/strong>).&nbsp;<\/p>\n\n\n\n<p>\u201cNanox already sells silver nanoparticles worldwide and could benefit a great deal from the new technique for obtaining the material,\u201d Longo said.<\/p>\n\n\n\n<p>The researchers plan to evaluate use of the material in dental prosthetics and have begun trials to investigate the action of nanocomposites in cancer cells.&nbsp;<\/p>\n\n\n\n<p>Preliminary results of the experiments suggest the nanoparticles can eliminate tumor cells without affecting healthy cells.<\/p>\n\n\n\n<p>The\u00a0<em>Scientific Reports<\/em>\u00a0article \u201cTowards the scale-up of the formation of nanoparticles on \u03b1-Ag2WO4 with bactericidal properties by femtosecond laser irradiation\u201d (doi:10.1038\/s41598-018-19270-9) by Marcelo Assis, Eloisa Cordoncillo, Rafael Torres-Mendieta, H\u00e9ctor Beltr\u00e1n-Mir, Gladys M\u00ednguez-Vega, Regiane Oliveira, Edson R. Leite, Camila C. Foggi, Carlos E. Vergani, Elson Longo and Juan Andr\u00e9s can be read at:\u00a0<strong><a rel=\"noreferrer noopener\" href=\"https:\/\/www.nature.com\/articles\/s41598-018-19270-9\" target=\"_blank\">nature.com\/articles\/s41598-018-19270-9<\/a><\/strong>.<\/p>\n\n\n\n<p><strong>Link to original article:<\/strong> <a href=\"http:\/\/agencia.fapesp.br\/novel-technique-achieves-32-fold-increase-in-bactericidal-capacity-of-nanoparticles\/27698\/?fbclid=IwAR1tZziYJ_KBCmUoM0HzsgB72-B8hC9yAreYgBJlM_u7joba3JwdfzwThXQ\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"http:\/\/agencia.fapesp.br\/novel-technique-achieves-32-fold-increase-in-bactericidal-capacity-of-nanoparticles (opens in a new tab)\">http:\/\/agencia.fapesp.br\/novel-technique-achieves-32-fold-increase-in-bactericidal-capacity-of-nanoparticles<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>By Elton Alisson&nbsp; |&nbsp; Ag\u00eancia FAPESP&nbsp;\u2013 In recent decades, various research groups in the field of materials science have embarked on a race to develop new techniques capable of producing nanometric silver particles and enhancing <a class=\"mh-excerpt-more\" href=\"https:\/\/cdmf.org.br\/en\/2018\/05\/02\/novel-technique-achieves-32-fold-increase-in-bactericidal-capacity-of-nanoparticles\/\" title=\"Novel technique achieves 32-fold increase in bactericidal capacity of nanoparticles\">[&#8230;]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":100,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[9],"tags":[],"class_list":{"0":"post-99","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-news"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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