Development of Co-3[Co(CN)(6)](2)/Fe3O4 Bifunctional Nanocomposite for Clinical Sensor Applications

Abstract: In this study, a magnetically separable three-dimensional (3D) Co-3[Co(CN)(6)](2)/Fe3O4 nanocomposite comprising magnetic nanoparticles (NPs) adsorbed on the nanocubes of a cobalt Prussian blue analogue was prepared. The nanocomposite exhibited enhanced electrochemical performance in Co2+/Co3+ conversion, while the superparamagnetic behavior of the magnetite NPs was preserved even after adsorption on the nanocubes. Increased Faradaic currents were observed in the cyclic voltammograms (CV) for Co-3[Co(CN)(6)](2)/Fe3O4 in comparison with the CV of isolated Co-3[Co(CN)(6)](2). This increase was attributed to supramolecular charge transfer between the cobalt Prussian blue analogue and the magnetic NPs and the larger amount of electroactive species on the electrode. Transmission electron microscopy images showed well-defined Co-3[Co(CN)(6)](2) nanocubes that had edge lengths of 21-140 nm and were decorated with spherical magnetite NPs less than 10 nm in diameter. Interestingly, an intimate contact between the nanocubes and aggregate formation was avoided by Fe3O4 NPs. The composition, morphology, and surface properties of the nanohybrid material were assessed by UVvis absorption spectroscopy, FTIR spectroscopy, X-ray diffraction, scanning electron microscopy, and Brunauer-Emmett-Teller surface area. The analytical results of nanocomposite showed main bands, crystalline phases, and structures associated with Fe3O4 and Co-3[Co(CN)(6)](2). The bifunctional properties of Co-3[Co(CN)(6)](2)/Fe3O4 are potentially useful for building novel (bio)sensors and magnetic devices for clinical applications.

Author(s): Carvalho, CLC; Silva, ATB; Luz, RAS; Castro, GMB; Lima, CD; Mastelaro, VR; da Silva, RR; Oliveira, ON; Cantanhede, W

ACS APPLIED NANO MATERIALS

DOI: 10.1021/acsanm.8b01106