Kinetic Control of Microtubule Morphology Obtained by Assembling Gold Nanoparticles on Living Fungal Biotemplates

Bioconjugate Chem. 2016, 27, 2337−2345

Figure: SEM images of hybrid microtubules obtained using biotemplates of Penicillium brasilianum after successive additions of gold nanoparticles, forming microtubules with wall thicknesses of 80−500 nm. These images show microtubules with controlled thickness obtained after adding new colloidal suspensions of gold nanoparticles to the system.
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Writers: Kubo, Andressa M. and Gorup, Luiz F. and Amaral, Luciana S. and Filho, Edson R. and Camargo, Emerson R.

Keywords: Gold; Nanoparticles; Morphological; Microtubules

Abstract: Self-assembly of nanoparticles on living biotemplate surfaces is a promising route to fabricate nano- or microstructured materials with high efficiency and efficacy. We used filamentous fungi to fabricate microtubules of gold nanoparticles through a novel approach that consists of isolating the hyphal growth from the nanoparticle media. This improved methodology resulted in better morphological control and faster adsorption kinetics, which reduced the time needed to form homogeneous microtubules and allowed for control of microtubule thickness through successive additions of nanoparticles. Differences in the adsorption rates due to modifications in the chemical identity of colloidal gold nanoparticles indicated the influence of secondary metabolites and growth media in the fungi metabolism, which demonstrated the need to choose not only the fungus biotemplate but also the correct medium to obtain microtubules with superior properties.

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