Thermosensitive and Biocompatible Nanocomposites of Poly(N-vinylcaprolactam) and Hydroxyapatite with Potential Use for Bone Tissue Repair
Abstract: Thermosensitive nanocomposites of poly(N-vinylcaprolactam) and hydroxyapatite nanoparticles synthesized by hydrothermal processing were prepared by in situ polymerization in dimethyl sulfoxide, using azobisisobutyronitrile as a radical initiator. Polymerization was performed in the presence of nanoparticles (1% w/w) at 70 °C during 4 h to obtain a new stimuli-responsive biomaterial for medical/dental applications. The biocompatibility of the injectable nanocomposites was verified through the survival ratio and eclosion ratio of zebrafish embryos, which revealed a polymer of low toxicity, showing an average survival ratio of 93% after 96 h of exposition up to 25% of nanocomposites in water. In this sense, this work introduces an injectable hydrogel biomaterial with potential osseointegration properties for bone tissue engineering.
Author(s): Assis, J. F.; Gabriel, A. M.; Goncalves, L. F.; Machado, M. R. F.; Morgado, D. L.; Sala, R. L.; Cristovan, F. H.; Oliveira, M. P.; Arantes, T. M.; Camargo, E. R.
Bionanoscience
Published: 17 June 2022
DOI: https://doi.org/10.1007/s12668-022-00988-w
CDMF
The CDMF, hosted at the Federal University of São Carlos (UFSCar), is one of the Research, Innovation and Dissemination Centers (RIDC) supported by the São Paulo State Research Support Foundation (Fapesp), and also receives investment from the National Council Scientific and Technological Development (CNPq), from the National Institute of Science and Technology of Materials in Nanotechnology (INCTMN).
